Seminar on how to prevent disease by Chen Chen
-- 5/11 1:00pm at Chinese School Room #208
Note： Chen Chen received a PhD in nutritional science and has worked in food, dietary supplement, and pharmaceutical industries for 20 years.
Endothelial Glycocalyx: A New Paradigm in Understanding and Managing Cardiovascular Related Diseases
The glycocalyx is a gel-like layer lining the luminal side of the endothelium in all blood vessels. It provides a micro-environment for many vital processes in the vascular system. Glycocalyx has been demonstrated to limit the accessibility of lipids and proteins and to form a barrier for adhesion of platelets and inflammatory cells to the vascular wall. It plays a central role in mechanosensing and transduction of hemodynamic stimuli to the endothelium, thereby regulating the production of among many others nitric oxide. Damage of the glycocalyx is associated with impaired endothelial functions, which has been implicated in the pathologies of atherosclerosis, diabetes, hypertension, stroke, kidney failure, and Alzheimer’s disease, just to name a few. While pharmaceutical modalities are being developed, life style changes such as dietary modification and supplementation can be used effectively to restore damaged glycocalyx and, therefore, to improve the related health conditions.